| ULB Research ⤶ |
Description of the Unit | Projects of the Unit | Composition |
| Collaborations of the Unit | Protected technologies | Publications | Skills |
Structure and Function of Biological Membranes (SFMB)
Faculty of Sciences | Chemistry
(Code: ULB167)
► Study of the properties and the regulation of ion channels
No funding agency referenced.
Ion channels play a key role in energy and solute exchanges between cellular compartments and their environment. Moreover, they are involved in numerou ...
► Development of cationic liposomes as carriers for genetic material
No funding agency referenced.
Our group has developed a new class of cationic liposomes for gene transfer in eukaryote cells both in vitro and in vivo. Development of new vectors wi ...
► Expression and structural analysis of several 'ABC, ATP Binding Cassette' proteins involved in cell resistance
No funding agency referenced.
Resistance proteins (Pgp, MRP, Lmr A, Hor A) are expressed in the plasma membrane. They are able to reject pharmacological agents outside the cells and ...
► Apolipoproteins
No funding agency referenced.
Exchangeable apolipoproteins play a critical role in plasma lipoprotein metabolism, first as structural components of lipoproteins, but also as activat ...
► Proteomics
No funding agency referenced.
Identification by mass spectrometry of proteins expressed during cellular environment modification after separation by two-dimensional eletrophoresis o ...
► Design and building of biosensors
No funding agency referenced.
We design and set up devices suitable for the investigation of ligand-receptor interactions, in particular for the investigation of an analyte target i ...
► Traduction
No funding agency referenced.
Traduction
► Computer-assisted molecular modeling and simulations of the structure, thermodynamics and dynamics of biological macromolecules. Study of the association between biological macromolecules
No funding agency referenced.
- Some membrane proteins (ABC transporters) develop resistance to drugs by rejecting pharmacological agents (anticancer agents, antibiotics, ...) to th ...
► Rational drug design
No funding agency referenced.
Discovery of new drugs is a process in which bioinformatics tools play nowadays an important role. - D-alanine:D-alanine ligase : The emergence of bact ...
► Structure and mode of action of lung surfactants
No funding agency referenced.
Modification in pulmonary surfactant composition is associated to several pathologies : asthma, pneumonia, respiratory distress syndroma. Our objective ...
► Traduction
No funding agency referenced.
Traduction
► Mechanism of bacterial pathogenicity : toxins (diphtheria, anthrax) and invasines (S. flexneri and Y. enterocolitica)
No funding agency referenced.
Bacterial pathogenicity often involves translocation of bacterial virulence factors across cell membranes. Our goal is to molecularly characterize this ...
► Structure-function studies of secondary bacterial transporters, involved in multidrug resistance and the role of the lipidic environment on their activity.
No funding agency referenced.
Secondary transporters that belong to the MFS (Major Facilitator Superfamily) represent a model of choice to decipher, at the molecular level, the phen ...
► Characterization of the RND systems involved in the bacterial mechanisms of heavy metal resistance.
No funding agency referenced.
The objective of this research is to study at the molecular level the binding and the specific transport of heavy metal ions across the membrane comple ...
