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Ano1 opening in ; cells induces Cl- efflux resulting in plasma membrane depolarization and opening of L-typeCa2+channels when their threshold is reached. Bursts of action potentials then increase intracellular Ca2+ and induce insulin secretion. Present investigations focus on (i) how does glucose induce Ano1 opening with the hypothesis on a role of ryanodine channels as responsible of a localized increase in intracellular Ca2+, particularly; (ii) how does the ;-cell increases its intracellular Cl- content after Cl- discharge through Ano1 channels with special emphasis on a possible Cl- sensing role of kinases with-no- lysine (WNK). Activation of one of these kinases could lead to activation of the Na-K-2Cl cotransporters.
• F.R.S.-FNRS et Fonds associés (hors FRIA)
• Fonds spéciaux de recherche