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In vivo gene delivery in the brain using adeno-associated virus-based (AAV) vectors. We have shown that AAV vectors can drive stable gene expression (at least one year) in the brain with however a variable efficacy and durability. In the globus pallidus, gene expression es early and efficient whereas in the striatum, a potential target for the treatment of Huntington and Parkinson's diseases, it is stable but not efficient. New vectors developed in another theme are currently evaluated.
• F.R.S.-FNRS et Fonds associés (hors FRIA)
• Fonds associés (toutes subventions, y compris la Loterie Nat.)
• Autres fonds publics belges
• Autres U.E.