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Dedicated to applied and fundamental research, the Laboratory of Experimental Hematology is articulated around three main subjects: 1. study of the inhibition mechanisms of cancer cells rejection by the immune system to better understand how the tumoral microenvironement support and allow the growth of leukemic cells;2. discovery of new tumoral environment biomarkers predictive of patient prognosis and treatments response;3. study of the role of non-coding RNA in oncogenesis in a viro-induced leukemia model.Today, in most of the case, the autologus system is unable to eradicate residual leukemic cells that escape radio-chemotherapy. The high relapse rate in cancers gives evidence of this inefficacy of the immune system to control residual cancer cells. Therefore, the current issue is to understand the immune environment of cancer and the interactions between cancer cells and the immune system. A particular aspect is the understanding of the mechanisms leading to the generation, in the context of leukemia, of T regulatory lymphocytes. regulatory T cells are actively engaged in the maintenance of immunological tolerance by suppressing reactive T cells. The use of a viro-induced leukemic model allows us to unveiled molecular mechanisms potentially involved in tumor progression. All these knowledge are critical to discover optimal immune-modulation modalities to obtain a powerful and sustained anticancer effect.
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