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Laboratory of Experimental Hematology (HEMEXP)

Faculty of Medicine | Bordet Institute

Interfaculty institutes | Institute of Research in Immunology

Interfaculty institutes | U-CRC: ULB Cancer Research Center

(Code: ULB612)


Person in charge of the unit : BRON Dominique.

Dedicated to applied and fundamental research, the Laboratory of Experimental Hematology is articulated around three main subjects: 1. study of the
inhibition mechanisms of cancer cells rejection by the immune system to better understand how the tumoral microenvironement support and allow the growth of
leukemic cells;2. discovery of new tumoral environment biomarkers predictive of patient prognosis and treatments response;3. study of the role of non-coding RNA
in oncogenesis in a viro-induced leukemia model.Today, in most of the case, the autologus system is unable to eradicate residual leukemic cells that escape
radio-chemotherapy. The high relapse rate in cancers gives evidence of this inefficacy of the immune system to control residual cancer cells. Therefore,
the current issue is to understand the immune environment of cancer and the interactions between cancer cells and the immune system. A particular aspect is
the understanding of the mechanisms leading to the generation, in the context of leukemia, of T regulatory lymphocytes. regulatory T cells are actively
engaged in the maintenance of immunological tolerance by suppressing reactive T cells. The use of a viro-induced leukemic model allows us to unveiled
molecular mechanisms potentially involved in tumor progression. All these knowledge are critical to discover optimal immune-modulation modalities to obtain a
powerful and sustained anticancer effect.

Campus : Institut Jules Borde
Location : Institut Bordet - 5ème étage
Address : CP401/06 Bruxelles
Phone number : +32-2-541.37.16
Fax : +32-2-541.34.53
E-mail : catherine.primo@bordet.be