Units

J.-C. Heuson Breast Cancer Translational Research Laboratory

Person in charge of the Unit : Oui

Breast Cancer Translational Research Laboratory (BCTL)
The BCTL has a considerable track record in using state-of-the-art “omics” technologies to improve the molecular understanding of breast cancer biology and to derive prognostic and predictive biomarkers in order to accelerate the translation of basic science discoveries into the clinical practice.

Applied Cancer Epigenomics and Epitranscriptomics (ACEE)
Our research is focused on the detection of changes in DNA and RNA modifications in clinical samples of cancer patients using state-of-the-art sequencing technologies. We utilize these changes to improve the stratification of cancer patients for outcome and treatment choice, to identify new targets for cancer therapy and to gain new insights into tumor biology.

Cancer Ecosystems and Metastasis Lab (CEMLab)

Projetcs

MAPPING TRIPLE NEGATIVE BREAST CANCER HETEROGENEITY BY LEVERAGING SPATIAL TRANSCRIPTOMICS AND ARTIFICIAL INTELLIGENCE: TOWARDS AN OPTIMIZED PATIENTS’ CARE

Porteurs de projet : Christos Sotiriou, Françoise Rothé, David Venet, Nicola Occelli

UNCOVERING THE IMMUNE LANDSCAPE OF BREAST CANCER

Porteurs de projet : Christos Sotiriou, Laurence Buisseret, Françoise Rothé
Collaborations : Prof John Stagg CR-CHUM, Montreal, Canada

CHARACTERIZATION OF ENDOCRINE RESISTANT LUMINAL BREAST CANCER USING SPATIAL TRANSCRIPTOMICS AND EPIGENETIC ANALYSIS

Porteurs de Projet : Christos Sotiriou, Françoise Rothé and Mattia Rediti
Collaborations : 
Dr François Fuks, Laboratory of Cancer Epigenetics, ULB-Cancer Research Center (U-CRC), Université libre de Bruxelles
Prof Lundeberg at the SciLife laboratory, Stockholm, Sweden
Dr Frédérick Libert, ULB/VUB Brightcore sequencing facility

MOLECULAR CHARACTERIZATION OF BREAST CANCER HETEROGENEITY USING SPATIAL TRANSCRIPTOMICS AND SINGLE CELL ANALYSIS

•	Porteurs de projets : Christos Sotiriou, Françoise Rothé
•	Collaborations : 
       o	Prof. Lundeberg at the SciLife laboratory (Stockholm, Sweden)
       o	Dr Frédérick Libert, ULB/VUB Brightcore sequencing facility

TRACKING TUMOR EVOLUTION AND DISTANT RECURRENCE IN BREAST CANCER BY MODELING TUMOR DORMANCY AND THE MOLECULAR CLOCK RATE

Porteurs de projet : Christos Sotiriou, Françoise Rothé, David Venet et Danai Fimereli

MOLECULAR CHARACTERIZATION OF INTRATUMOR HETEROGENEITY AND TUMOR MICROENVIRONMENT IN HIGH GRADE SEROUS OVARIAN CANCER AND BRCA1/2 MUTANT BREAST CANCER USING SPATIAL TRANSCRIPTOMICS

Porteurs de projet : Christos Sotiriou, Françoise Rothé
Collaborations : Prof Isabelle Ray-Coquard (Centre Léon Bérard, Lyon)

DISSECTING THE IMPACT OF INTRATUMOR HETEROGENEITY ON DISEASE RELAPSE IN LUMINAL BREAST CANCER IN THE CONTEXT OF THE MINDACT CLINICAL TRIAL

Porteurs de projet : Christos Sotiriou, Françoise Rothé, Laetitia Collet
Collaborations : Prof. Christine Desmedt, Marion Maetens, PhD (KU Leuven)

INTERROGATING THE FUNCTIONAL RELEVANCE OF A-TO-I RNA EDITING IN BREAST CANCER

Porteurs de projet : Christos Sotiriou, Françoise Rothé, David Venet, Floriane Dupont
Collaborations : Prof Vincent Detours, IRIBHM, Université libre de Bruxelles

MOLECULAR CHARACTERIZATION OF TRIPLE-NEGATIVE BREAST CANCER USING SPATIAL TRANSCRIPTOMICS AND SINGLE CELL ANALYSIS.

Porteurs de projets : Christos Sotiriou, Françoise Rothé
Collaborations : 
Prof. Lundeberg at the SciLife laboratory (Stockholm, Sweden)
Dr Frédérick Libert, ULB/VUB Brightcore sequencing facility