Units

J.-C. Heuson Breast Cancer Translational Research Laboratory

Person in charge of the Unit : Oui

Dr. Sotiriou and his team developed several prognostic and predictive genomic signatures, of which the most representative is the 'Genomic grade Index' (GGI) that allow patients classification into different prognostic groups following their disease history and the different benefice to chemo or hormonal-therapy. The team was also one of the first to develop a gene signature summarizing the immune function, showing the importance of the microenvironment in the natural history of the disease and in the response to treatment.Ongoing Research: Molecular characterization of breast cancer using next generation sequencing techniques; Identification of prognostic and predictive markers in breast cancer ; Evaluation of the role of the tumor microenvironment (including immune components) in breast tumor invasion/dissemination ; Molecular characterization of the minimal residual disease (circulating (CTCs) and disseminated (DTCs) breast tumor cells ; Study of epigenetic changes associated with breast tumor genesis and response to different therapeutics ; Studies of functional readouts of key molecular pathways involved in breast tumor genesis and response to different treatments including targeted agents.

Projetcs

TRACKING TUMOR EVOLUTION AND DISTANT RECURRENCE IN BREAST CANCER BY MODELING TUMOR DORMANCY AND THE MOLECULAR CLOCK RATE

Porteurs de project : Christos Sotiriou, Françoise Rothé, David Venet et Danai Fimereli

INTERROGATING THE FUNCTIONAL RELEVANCE OF A-TO-I RNA EDITING IN BREAST CANCER

Porteurs de projet : Christos Sotiriou, Françoise Rothé, David Venet, Floriane Dupont
Collaborations : Prof Vincent Detours, IRIBHM, Université libre de Bruxelles

MOLECULAR CHARACTERIZATION OF TRIPLE-NEGATIVE BREAST CANCER USING SPATIAL TRANSCRIPTOMICS AND SINGLE CELL ANALYSIS.

Porteurs de projets : Christos Sotiriou, Françoise Rothé
Collaborations : 
Prof. Lundeberg at the SciLife laboratory (Stockholm, Sweden)
Dr Frédérick Libert, ULB/VUB Brightcore sequencing facility

UNCOVERING THE IMMUNE LANDSCAPE OF BREAST CANCER

Porteurs de projet : Christos Sotiriou, Laurence Buisseret 
Collaborations : Prof John Stagg CR-CHUM, Montreal, Canada

CHARACTERIZATION OF ENDOCRINE RESISTANT LUMINAL BREAST CANCER USING SPATIAL TRANSCRIPTOMICS AND EPIGENETIC ANALYSIS

Porteurs de Projet : Christos Sotiriou, Françoise Rothé and Mattia Rediti
Collaborations : 
Dr François Fuks, Laboratory of Cancer Epigenetics, ULB-Cancer Research Center (U-CRC), Université libre de Bruxelles
Prof Lundeberg at the SciLife laboratory, Stockholm, Sweden
Dr Frédérick Libert, ULB/VUB Brightcore sequencing facility