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GONZE Didier


Unit of Theoretical Chronobiology

Person in charge of the Unit : Oui

In the Unit of Theoretical Chronobiology, we investigate by means of theoretical models the molecular bases of biological rhythms and threshold phenomena at the cellular level. Our modeling approach primarily pertains to the oscillations and waves of cytosolic calcium, the circadian clock, the cell cycle, and cellular differentiation. We also focus on physiological implications of these processes and on their associated pathological disorders. In this context, we study the origin of calcium deregulations leading to infertility or Alzheimer's disease, as well as sleep phase disorders linked to dysfunction of the circadian clock, but also the influence of circadian rhythms on cell proliferation and cancer.


Modeling the dynamics of the mammalian cell cycle.

Modeling the sequential activation of the pairs of cyclins and cyclin-dependent kinases (Cdks) controlling the successive phases of the cell cycle.