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Unit of Theoretical Chronobiology (UTC)

Faculty of Sciences | Chemistry

Interfaculty institutes | IB²: Interuniversity Institute of Bioinformatics of Brussels

(Code: ULB494)

Person in charges of the unit : DUPONT Geneviève, GONZE Didier, LELOUP Jean-Christophe.

In the Unit of Theoretical Chronobiology, we investigate by means of theoretical models the molecular bases of biological rhythms and threshold phenomena
at the cellular level. Our modeling approach primarily pertains to the oscillations and waves of cytosolic calcium, the circadian clock, the cell cycle, and
cellular differentiation. We also focus on physiological implications of these processes and on their associated pathological disorders. In this context,
we study the origin of calcium deregulations leading to infertility or Alzheimer's disease, as well as sleep phase disorders linked to dysfunction of the
circadian clock, but also the influence of circadian rhythms on cell proliferation and cancer.

Campus : Campus de la Plaine
Location : Campus Plaine, bâtiment NO, niveau 5, local 2.O5.105 / 2.O5.114
Address : CP231
Phone number : +32-2-650.57.94 / +32-2-650.57
Fax : +32-2-650.57.67
E-mail :,
Web site :

Disciplines CRef :

 • Biophysics

 • Cell biology

 • Soil biology - disinfection (plant biochemistry)

 • Theoretical biology

 • Theoretical chemistry