Units

Laboratory of Experimental Neurology

1. Study of the genetic predisposition to epilepsy and to antieplieptic treatment response (pharmacogenetics).2.Investigations on the pathogenesis of Friedreich ataxia and development of new cellular and animal models.3. Development of the induced pluripotent stem cell (iPS) technology for nervous system disease modeling (epilepsy, ataxia). 4. Mechanisms of frataxin gene silencing in Friedreich ataxia and development of therapeutic approaches to restore frataxin gene expression. 5. Investigations on cerebellar physiology and biochemistry by combining microdialysis and neurophysiological recordings on animal models (rodents).

Projetcs

Investigations on cerebellar physiology and biochemistry by combining microdialysis and neurophysiological recordings on animal models (rodents).

Analysis of neurotransmitters and of neural activity in the rodent cerebellum in normal and pathological (toxic, degenerative) conditions.