Laboratory of Cancer Epigenetics

Faculty of Medicine | Erasme Campus

Interfaculty institutes | U-CRC: ULB Cancer Research Center

(Code: ULB589)

Person in charge of the unit : FUKS François.

The Laboratory of Cancer Epigenetics headed by François FUKS is interested in investigating the epigenetic mechanisms involved in health and disease, with
a focus on DNA and histone modifications (e.g.: Viré et al. Nature 2006 ; Brenner et al. Dev Cell 2007 ; Villa et al. Cancer Cell 2007 ; Fuks F. Nature.
2010 ; Ndlovu et al. Trends Biochem Sci. 2011 ; Deplus et al. Cell Rep. 2014 ; Delatte et al. EMBO J. 2014 ).It is now clear that the roles play by
epigenetic alterations in a growing number of medical conditions unfold the attractive opportunity to develop epigenetic therapies that promises to reshape the
diagnostic and therapeutic arena (personalised medicine). In the last few years, the field of epigenetic has expanded into an essential component of
biological and medical research, with modifications of DNA and histones being considered hallmarks of most human diseases, including cancer. Further, the
epigenetic field has recently evolved from a gene-by-gene approach to a more global approach, with far-reaching clinical implications in the field of diagnosis and
treatment. Essential to these efforts are the development of technologies to explore genome-wide epigenetic modifications. In line with these recent
developments, François Fuks' team has also a deep interest in the generation of novel epigenomic technologies in health and diseases (e.g.; Dedeurwaerder et al.
EMBO Mol Med 2011; Volkmar et al. EMBO J 2012; Deplus et al. EMBO J 2013; Boumahdi et al. Nature 2014). Technologies such as ChIP-Seq, RNA-Seq, Infinium
Methylation are routinely used by the lab, which is heading the Epigenomics Core facility, EPICS.

Campus :	Campus Hospitalo-Fac
	Campus Erasme
Location :	Bât. GE - 5e niveau - local G2.5.210
Address :	CP614 Bruxelles
Phone number :	+32-2-555.62.35
Fax :	+32-2-555.62.57
E-mail :	imazza@ulb.ac.be
Web site :	http://www.ulb.ac.be//medecine/fukslab/index.html

Disciplines CRef :

• Cancerology

• Cell biology

• Molecular biology

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