The work of the group consists in the definition at the molecular level of the mechanisms and enzymes involved in the signal
termination reaction of new important intracellular molecules. The defined mechanisms, the cloning of new enzymes such as InsP3
3-kinases, 5-phosphatases, SHIP1 and SHIP2 have introduced new concepts and new targets in pharmacology. Loss of SHIP2 in mice leads to
increased sensitivity to insulin.