|Faculty / Departement||Register by Units||Register by Projects||Register of researchers|
|Register by Collaborations||Ranking by Domains||Ranking by Frascati||Disciplines CREF|
After having pioneered the cloning by homology of rhodopsin-like GPCRs in the late eighties, the Institute has built expertise in the study of a variety of GPCR subfamilies. These include mainly the glycoprotein hormone receptors, receptors for chemokines and other leucocyte chemoattractants, adenosine receptors, P2Y nucleotide receptors, cannabinoid receptors. Studies include structure-function relationships (glycoprotein hormone receptors, chemokine receptors, purinergic receptors), regulation of downstream cascades and gene expression by microarrays (leucocyte receptors), in vivo phenotypic studies of mice with invalidated receptor genes (adenosine A2a receptor, cannabinoid CB1 receptor, prolactin-releasing peptide receptor, P2Y4, P2Y6 and P2Y13 receptors, orphan receptors). The group studies also GPCR dimerization and the pharmacological and functional consequences of this process. In addition, a strong emphasis is put on the identification of the natural agonists of a wide diversity of orphan GPCRs, and the functional characterization of these receptors in physiology, human diseases and animal models.
• F.R.S.-FNRS et Fonds associés (hors FRIA)
• Fonds associés (toutes subventions, y compris la Loterie Nat.)
• Fonds spéciaux de recherche
• Actions concertées
• Région wallonne
• Autres U.E.
• Entreprises privées
• Entreprises étrangères
• Financement de base institutionnel