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Units : Computational Biology & Bioinformatics | ULB821
The control of physicochemical and biological properties of proteins is a major challenge in all biotechnology sectors. Indeed, proteins are increasingly used as catalysts for their high specificity and performance in the development of environmentally friendly bioprocesses. In addition, therapeutic proteins, monoclonal antibodies and protein vaccines are of key importance for the biopharmaceutical field. With the rise of structural bioinformatics, it becomes feasible to rationally design optimized biological molecules. Even though the in silico approaches cannot lead to ideal success rates given the extreme complexity of biological systems, they make it nevertheless possible to propose a limited number of candidate molecules to be validated experimentally. This drastically reduces the number of experiments, which has a series of positive effects such as reduced costs, decrease and better targeting of animal experimentation, and the advent of a general technology that is more compatible with sustainable development.
• F.R.S.-FNRS et Fonds associés (hors FRIA)