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Contribution to the assessment of drug antioxidant capacity in the myeloperoxidase system

Units : Pharmacognosy, Bioanalysis & Drug Discovery | ULB400

Description :

Myeloperoxidase (MPO) is an enzyme produced by neutrophils during inflammatory reactions. If its first role is struggling antigens
by producing hypochlorous acid, this enzyme is involved in chronic inflammatory syndromes such as atherosclerosis. This leads us
to develop specific MPO inhibitors. In addition, we are studying the impact of the enzyme in cardiovascular diseases (MPO-LDL
interaction, oxidative damage...). Moreover, we characterize the inhibitor mechanisms by studying spectral properties of the enzyme
and by identifying reaction products.

List of persons in charge :

  • COREMANS Catherine

  • DELPORTE Cédric

List of lessors :

  • F.R.S.-FNRS et Fonds associés (hors FRIA)

  • Financement de base institutionnel