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Translational projects to better understand pathogenesis of pulmonary hypertension, lung vascular remodeling and effects on the myocardium in order to identify new therapeutic targets. Current projects relate to: (a) the effects of adipokines (leptin and chemerin) and of BMPR2 and endothelin-1 signaling pathways on endothelial dysfunction, remodeling and intercellular communication within the pulmonary arteriolar wall; (b) the pathogenesis of right heart failure and the role of SDF-1; (c) the impact of brain death on pulmonary circulation and right heart.
• F.R.S.-FNRS et Fonds associés (hors FRIA)
• Fonds spéciaux de recherche