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Cyclic nucleotide phospho-diesterases and sepsis

Units : Laboratory of Experimental Medicine(CHU Charleroi-Hop Vesale) | ULB222

Description :

Cyclic nucleotide phosphodiesterases (PDE)regulate the intracellular levels of cAMP and cGMP and are ubiquitously distributed in
mammalian tissues.An increasing number of studies have pointed out links between inflammation and PDE, providing a rationale for
studying PDE inhibitors in the treatment of inflammatory conditions and particularly sepsis.