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Characterization of the AU-rich dependent mecanism of messenger RNAs degradation in Drosophila melanogaster.

Units : Molecular biology of the gene | ULB130

Description :

Secretion of antimicrobial peptides (AMP) is a central defense mechanism used by invertebrates to combat infections. In
Drosophila, the synthesis of these peptides is a highly regulated process allowing their rapid release in the hemolymph upon contact with
pathogens and the arrest of their production after pathogen clearance. We observed that AMP genes have either a transient or
sustained expression profile in S2 drosophila cells treated with peptidoglycan. Moreover, AMP genes containing AU-rich elements (ARE) in
their 3' untranslated region (UTR) are subject to a post-transcriptional control affecting mRNA stability, thereby contributing to
their transient expression profile. Cecropin A1 (CecA1) constitutes the prototype of this latter class of AMPs.

List of persons in charge :

  • GUEYDAN Cyril

  • KRUYS Véronique

List of lessors :

  • F.R.S.-FNRS et Fonds associés (hors FRIA)

  • Financement de base institutionnel

  • Fonds propres (patrimoine)