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Molecular mechanisms of frataxin gene silencing in Friedreich ataxia and therapeutic approaches to restore gene expression.

Units : Laboratory of Experimental Neurology | ULB256

Description :

Chromatin and DNA binding proteins analysis in the frataxin gene in the presence of the Friedreich ataxia mutation (GAA expansion)
and reactivation of gene expression by using designed DNA ligands and histone deacetylase inhibitors.

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