The IRIBHM has developped a mouse transgenic facility in the latest eighties. Addition transgenesis, by microinjection of DNA
constructs into fertilized mouse eggs, and gene replacement, resulting from the genetic manipulation of embryonic stem cells (ES), are
available in the institute. These techniques have been used to generate models of thyroid diseases and to study the role in vivo
of G protein coupled receptors, signalling proteins and factors involved in axonal guidance