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In response to a stimulation by a hormone or a neurotransmitter, most cells respond by repetitive increases of their intracellular calcium concentration. Moreover, each spike propagates as a wave both inside the cell and between adjacent cells. Using theoretical models developed in close collaboration with experimentalists, we study the mechanisms of these oscillations and waves, as well as their physiological roles. In particular, we develop coomputational tools allowing to investigate the role of calcium dynamics in physiological and pathophysiological porcesses such as secretion, fertilization or Alzheimer's disease.
• F.R.S.-FNRS et Fonds associés (hors FRIA)