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In the basal ganglia, recombinant vectors for gene transfer based on adeno-associated virus (AAV), a single-standed virus, transduce neurons of the globus pallidus and substantia nigra with a high efficiency. In contrast, transduction effeciency is low in the striatum. In order to identify the limiting steps in AAV-mediated gene transfer in the striatum, new vectors are currently evaluated: I) self-complementary vectors allowing the formation of double-standed DNA without the need for a cellular factor; II) non-viral vectors consisting in recombinant capsid protein of JCV, a papovavirus with a natural tropism for glial cells in the brain (collaboration with W. Lüke) and AAV DNA.
• F.R.S.-FNRS et Fonds associés (hors FRIA)
• Fonds associés (toutes subventions, y compris la Loterie Nat.)
• Autres fonds publics belges
• Autres U.E.