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The aim of this project is to determine the effect of a long-term treatment with drugs (ACE inhibitors, statins) on isolated rat and mice aortas. Some models of endothelial dysfunctions (incubation with oxidized LDL, nitrate tolerance, diabetic rate) are used to demonstrate and analyze the treatment effects. Part of work focus on endothelial-NO synthase (eNOS) knock-out mice.
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