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The aim is to understand the early mechanisms of the development of the human atheromatous process,studying interactions between endothelial cells,coagulation(fibrinolysis),inflammatory triggers like MPO oxydised LDL and the immune system ; the laboratory has developped an automated and reproducible method of fibriolysis measurement, a model of co-culture (endothelial cells - smooth muscle cells) is now being developped;the laboratory developps a model of endothelial cells culture exposed to a pulsatile flux;recombinant MPO and antibodies to MPO oxydized LDL are part of our tools.Owing to his position in a large general hospital,the laboratoty has access to large cohorts of patients,with their biological samples and clinical data, respecting the rules of the ethical commitees.
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