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The cerebral cortex is composed of hundreds of different types of neurons assembled in a highly organized structure. How cortical neurons are generated during embryonic development constitutes a major challenge in developmental neurosciences with implications for neural diseases. Our recent work has shown that the zinc finger transcription factor Dmrt5 and Dmrt3 are required for the development of the caudomedial part of the cerebral cortex. Our current work aims to better understand their function and mode of action in cortical patterning and neurogenesis.To achieve this, we are using a range of functional assays such as the analysis of transgenic and conditional knockout mice and gene overexpression and knockdown by electroporation in utero. We also study their transcription targets using expression profiling and chromatin immunoprecipitation (ChIP-seq) experiments.
• F.R.S.-FNRS et Fonds associés (hors FRIA)