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Study of the mechanisms of action of intracerebral implantation of foetal neurons in experimental models for Huntington's and Parkinson's diseases. Particularly, study of the neuroprotective and neurotrophic effects of intracerebral grafts of fetal neurons. We have evaluated the effects of fetal striatal grafts in an excitotoxic model for Huntington'disease consisting in injecting quinolinic acid, an agonist of NMDA receptor, in the adult rat striatum. We have shown that, although the grafted cells are poorly maintained, functional improvements could be observed (A. Lubansu). A higher survival of the grafted tissue could allow to enhance reinervation and improve the clinical benefit.
• F.R.S.-FNRS et Fonds associés (hors FRIA)
• Fonds associés (toutes subventions, y compris la Loterie Nat.)
• Autres fonds publics belges
• Autres U.E.