Units

ULB Center for Diabetes Research

Person in charge of the Unit : Oui

The Laboratory of Experimental Medicine investigates the molecular pathways involved in beta-cell impairment and apoptosis in diabetes. For this purpose, members of the laboratory use state of the art methodologies, such as functional genomics, exon arrays and RNA sequencing coupled to a systems biology approach, to unveil gene networks regulated by cytokines and free fatty acids.

Projetcs

Mechanisms of pancreatic beta-cell damage and repair in type 1 and 2 diabetes mellitus

We are utilizing modern molecular biological tools, such as microarray analysis and detailed studies of promoter regulation, to unveil the genes and transcription factors regulating the decision of the beta cells to undergo apoptosis in early diabetes mellitus and following islet transplantation.  Based on this information, we search for novel therapies for the disease.