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Laboratory of Bone and Metabolic Biochemistry The laboratory of Bone and Metabolic Biochemistry was established in April 2010 by Joanne Rasschaert in collaboration with Prof. Valérie Gangji, Head of the Service of Rheumatology and Physical Medicine at the Erasmus Hospital (Université libre de Bruxelles, Brussels). The creation of this new research unit which integrates fundamental and clinical research activities, allowed Profs Gangji and Rasschaert to combine their expertise in the fields of bone diseases, studies of physiological and pathological metabolic processes, signaling pathways and apoptosis. The research group is interested in understanding the mechanisms involved in bone diseases associated with dysfunction and death of bone marrow-derived mesenchymal stromal cells and mature osteoblasts.By combining in vitro and in vivo approaches, the research activities developed in the Laboratory intend to:- investigate the molecular mechanisms involved in the relations and synergies recently described between bone and energy metabolism;- clarify the cellular and molecular mechanisms involved in the development of bone diseases such as osteonecrosis, osteoporosis, osteoarthritis and non-unions (pseudarthrosis); - evaluate the role of bone marrow fat accumulation and altered lipid metabolism in the pathophysiology of osteoporosis and osteonecrosis;- identify new agents promoting differentiation, proliferation and survival of bone marrow mesenchymal stromal cells and osteoblasts in order to consolidate projects and clinical trials in bone cell therapy.
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