MAHJOUBI Mohamed Youssef
The research developed in the Laboratory of Organic Chemistry and Photochmeistry (COP) covers several aspects: design and synthesis of novel mono- and polynuclear Ru(II) complexes with polyazaaromatic ligands nanometer sized, design and synthesis of oligometallic and dendritic metallic complexes, study and development of novel potential anti-cancer drugs, activated under illumination and based on metallic compounds, development of metallic photoprobes and photoreagents of DNA, new molecular tools for the study of DNA, interaction of metallic complexes with nucleic acids, design and synthesis of Ru derivatized oligonucleotides for the anti-sens or anti-gene strategy, and for study of networks, photochemistry of Ru(II) complexes in the presence of amino acids, oligopeptides and proteins, synthesis of Rh(III), Ir(III), Cu(I), Cu(II) complexes as novel materials with particular optical or/and electronic properties, as well as the development and study of novel Cu(I) complexes used as photocatalysts for organic synthesis and carbon dioxyde photoreduction
The Laboratory of Organic Chemistry is active in organic chemistry in a broad sense, with research programs going from the development of new processes in organic chemistry and copper catalysis, the synthesis of bioactive/natural products, medicinal chemistry and the design, synthesis and study of molecular receptors derived from calixarenes. We are indeed interested in the synthesis of molecular receptors derived from calixarenes and the study of their host-guest properties toward neutral or charged species (metal ions, ammonium ions, anions). Macrocyclization reactions are used as the key-step for the syntheses of the receptors. The molecular recognition mechanisms are studied thanks to NMR spectroscopy. The receptors are then applied in the self-assembly of molecular objects, in chiral recognition, in catalysis, in surface modification, and in the design of modified electrodes or fluorescent molecular probes. Another part of our research is focused on the development of new processes and reagents in organic synthesis. One of the main area of research of this program is based on the use of copper catalysis and copper-mediated transformations. More specifically, we have been involved in the use of copper-catalysis in the synthesis of natural and/or bioactive products, for the development of new processes and reagents in organic synthesis and, more recently, in the development of new copper-catalyzed polymerization processes, all these research programs being strongly interconnected. We are in addition involved in the development of new processes based on new reagents or chemical intermediates.Moreover, the Laboratory of Organic Chemistry develops the synthesis of molecules of biological interest in collaboration with other groups from academia and industry.
Supramolecular photocatalytic water splitting (Perspect H20)
COST network "Supramolecular photocatalytic water splitting (Perspect H20)" in collaboration with several european laboratories (Coord: B.Dietzek).
Member of the managment committee