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Research focus on a better comprehension of different immunodeficiencies in humans. Three different immunodeficiency states are investigated, the immunodeficiency of childhood, the immunodeficiency of patients suffering from tuberculosis, and those associated with congenital immunodeficiencies. This work is at least partially based on the characterization of humoral and cellular immune responses to different infectious agents / or the correponding vaccine antigens. Therefore, we approach different questions of vaccinology with the hope to develop new strategies for better vaccine protection. In addition as the pathogens most often infect humans by the mucosal route, we characterize the immune reponses both within the blood and locally at the site of the infection. As we mostly aimed at the development of clinical immunology, our laboratory comprises medical doctors, scientists, and technicians.
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