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Department of Pathology

The main research themes of the laboratory focus on the identification and validation of new biomarkers in human cancers with diagnostic, prognostic and theragnostic purposes. The research activities combine fundamental and clinical aspects. For more than 15 years, our investigations have been focused on protein biomarkers in human tissue samples, animals and in vitro models. Immunohistochemistry (IHC) plays an essential role in the validation of these biomarkers because, as opposed to other biochemical approaches, this technology enables morphological control and thus protein localization at histological and cellular levels. A close collaboration with the Laboratory of Image Synthesis and Analysis (LISA, Ecole polytechnique, U.L.B., allows us to develop standardized tools for characterizing protein expression by using the multiple abilities provided by digital image analysis. From this collaboration was created the interfaculty unit, DIAPath (Digital Image Analysis in Pathology,, which is included in the Center for Microscopy and Molecular Imaging (CMMI, Biopark of Gosselies, know-how in biomarkers is often requested by other university and biotech research teams. These collaborations lead us to analyse human tumours from many origins as well as pathologic tissues from other diseases, such as inflammatory diseases, graft-versus-host or diabetes.


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