Laboratory of Pediatric Research
The Laboratory of Pediatric Research's primary activity is in newborn screening: systematic identification of newborns suffering from serious metabolic and endocrinological diseases, not yet clinically detectable at birth. Secondly, the laboratory carries out analyses central to the diagnosis and follow-up of metabolic diseases. The laboratory is continuously looking to develop novel techniques in this context.Newborn screening allows the detection of numerous rare, congenital diseases, undetectable at birth, that may have serious consequences for the infants concerned if not detected and treated in a timely fashion.Thanks to neonatal screening, the newborns inflicted with these disorders may be treated so that no symptoms appear and no irreversible damage occurs.
Research Project for Development (PRD): Investigation of the inlammatory response in infectious diseaes of the mother-infant dyad in Morocco
This is a university research project for development (PRD) funded by the Academy of Research and Higher Education (ARES) of the Wallonia-Brussels federation. It is a cooperation project between Belgian universities (the Université Libre de Bruxelles -the coordinating institution- and the Université Catholique de Louvain) and Moroccan universities and research institutes (University Hassan II of Casablanca, University Mohammed 6 of health sciences in casabmanca and the Pasteur Institute of Morocco).
Project title: INTEGRATED APPROACH FOR THE SUSTAINABLE CONTROL OF INFECTIOUS MORBIDITY AND MORTALITY IN THE MOTHER-CHILD DYAD IN MOROCCO
The project concerns the epidemiological study, the phenotypic and genotypic characterisation of antibiotic resistance of pathogenic bacteria and the investigation of the inflammatory parameters in infectious diseases in the mother-child dyad
Cellular and molecular basis of the sexual dimorphism on the immune inflammatory response in infectious and non-infectious inflammatory diseases
The morbidity and mortality associated with a number of infectious or non-infectious inflammatory diseases is variable according to the gender. While males are in general more susceptible to infection-induced acute inflammatory diseases, females are more vulnerable to chronic inflammatory diseases. This cannot be fully attributed to sexual hormones as this sexually dimorphic susceptibility is observed in pre-pubertal infants as well. We have reported a number of pediatric investigations showing that in chronic diseases such as cystic fibrosis and asthma, the inflammatory symptoms were more severe in girls than in boys. The objective of our research is to depict the cellular and molecular mechanisms underlying the sexual dimorphism of the immune inflammatory response with the aim to define a new molecular markers hat could be used in diagnosis and prognosis and also to pave the way for potential gender based therapy. To achieve our goal, we perform comparative studies in males and females suffering from acute or chronic inflammatory diseases by looking at i) biomarkers and cellular signaling involved in the inflammatory process in innate cells like neutrophils, monocytes and endothelial cells ii) X chromosome-linked molecular signatures such as genes involved in immunity and microRNAs that potentially regulate the inflammation. To test our hypothesis, we perform also in vitro and in vivo studies in animal models of infection and inflammation