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Biology of the Nucleus

Faculty of Sciences | Molecular Biology

(Code: ULB725)


Person in charge of the unit : FAHRENKROG Birthe.

Nuclear pore complexes (NPCs) are large protein assemblies that perforate the double membrane of the nuclear envelope (NE). They mediate all trafficking
between the nucleus and the cytoplasm of interphase cells and are composed of a set of different proteins, known as nucleoporins. Nucleoporins frequently
have additional functions in, for example, chromatin organisation, transcription and cell cycle progression, which are mainly independent of nuclear
transport. Therefore, nucleoporins are key players in overall nuclear organisation and intact nuclear organisation is critical for normal cell function. Our aim is
to understand the role of certain nucleoporins in human disease, acute leukaemia and a neuromuscular disorder known as fetal akinesia in particular .

Campus : Campus de Charleroi
Location : IBMM- Campus de Gosselies- bâtiment A - 4ème étage EST (A.E.4.108)
Address : CP300 - Rue Prof Jeener et Brachet, 12 - 6041 Gosselies
Phone number : +32-2-650.99.51/97.93
E-mail : bfahrenk@ulb.ac.be
Web site : http://www.ulb.ac.be/ibmm/bio-nucleus.html


Domain of the unit :


 • Immunology