Service of Molecular Virology (HIV-BLV-HTLV)

Faculty of Sciences | Molecular Biology

(Code: ULB126)

Person in charge of the unit : VAN LINT Carine.

The Laboratory of Molecular Virology is studying the role played by epigenetic modifications (histone acetylation, histone methylation and DNA methylation)
in transriptional latency and reactivation from latency of three retroviruses : HIV-1 (Human Immunodeficiency Virus type 1), HTLV-I (Human T-cell leukemia
virus I) and BLV (Bovine Leukemia Virus).Infection by these retroviruses is characterized by viral latency in the large majority of infected cells and by
the absence of viremia (in the cases of HTLV-I and BLV). These features are thought to be due to the transcriptional repression of viral expression in
vivo, but the molecular mechanisms involved in such a repression are not fully elucidated. The epigenetic modifications could be one mechanism by which these
viruses escape the host immune response and, in the case of HTLV-I/BLV, allow tumor development.

Campus :	Campus de Charleroi
Location :	IBMM, Aile Nord, niveau 3, portes 107 à 111 et 309
Address :	CP300 - Adrienne Bolland, 10 - 6041 Gosselies
Phone number :	+32-2-650.98.07 / 97.49
Fax :	+32-2-650.98.00
E-mail :	cvlint@ulb.ac.be
Web site :	http://www.ulb.ac.be/ibmm/home_15.html

Disciplines CRef :

• General virology

• Molecular biology

• Nucleic acids, protein synthesis

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