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Chloride channels and transporters involved in insulin secretion, special focus on anoctamin(s) channel(s).

Units : Laboratory of Physiology and Pharmacology | ULB230

Description :

Ano1 opening in ; cells induces Cl- efflux resulting in plasma membrane depolarization and opening of L-typeCa2+channels when
their threshold is reached. Bursts of action potentials then increase intracellular Ca2+ and induce insulin secretion. Present
investigations focus on (i) how does glucose induce Ano1 opening with the hypothesis on a role of ryanodine channels as responsible of a
localized increase in intracellular Ca2+, particularly; (ii) how does the ;-cell increases its intracellular Cl- content after Cl-
discharge through Ano1 channels with special emphasis on a possible Cl- sensing role of kinases with-no- lysine (WNK). Activation
of one of these kinases could lead to activation of the Na-K-2Cl cotransporters.

List of persons in charge :

  • GOLSTEIN Philippe

List of lessors :

  • F.R.S.-FNRS et Fonds associés (hors FRIA)

  • Fonds spéciaux de recherche