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Gonadotoxicity and pharmacological protection of the ovaries during chemotherapy

Units : Labo repro | ULB576

Description :

The laboratory has also developed an important clinical research activity in collaboration with oncological centers in Belgium and
abroad. The objectives are to study the impact of new therapies on ovarian function and to develop innovative pharmaceutical
approaches  in order to preserve fertility. The laboratory first investigated the protective effect of Gonadotropin-releasing hormone
(GnRHa) administrated during chemotherapy in patients with lymphoma (POF trial- NCT01160315). This study gave the opportunity to
the lab to develop a large network of international collaborations and to confirm his expertise in the evaluation of the
gonadotoxicity of chemotherapies.
The laboratory currently conduct several academic studies at national and international levels as
reference laboratory (POSITIVE  NCT02308085 ; AHL-2011 NCT01358747) or as promoter (BROVALE  NCT02661932 ; CHANCE NCT02595255 ; fAMHOPE).
Many retrospective studies have also been carried out in our laboratory and permit somes publications or TFEs.

Recently, the
laboratory developed new project to innovate in the pharmacological ovarian protection. As master regulators of genes
transcription, microRNAs showed high potential by regulating transcription and post-transcription of targeted genes involved in fundamental
cell functions including cell proliferation and apoptosis. Where miRNAs are used as genes modulators to increase the sensitivity of
the neoplasic cells to chemotherapy, they might also be useful to reduce toxicity in healthy cells. By studying the role of miRNAs
in follicular response to toxic agents, we aim to find a way to keep follicle healthy at the quiescent stage during

In addition, the lab is studying the impact of new anticancer treatments on the gonads, and more particularly for patients with
a genetic mutation predisposing to breast cancer (BRCA) thanks to the transgenic animal model and the use of the ovarian tissue
donated for the research.

List of persons in charge :

  • ALEXANDRI Chrysanthi

  • CONDORELLI Margherita

Members List :

  • ALEXANDRI Chrysanthi

  • CONDORELLI Margherita

  • DECHENE Julie

  • NTEMOU Elissavet

List of lessors :

  • F.R.S.-FNRS et Fonds associés (hors FRIA)

  • FRIA

  • Télévie

  • Fonds spéciaux de recherche

  • Organisations internationales