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Units : Laboratory of Cancer Epigenetics | ULB589
Epigenetic modifications are increasingly recognized as fundamental regulatory processes that are essential for a wide range of biological events and a key to far-reaching biotechnological and pharmaceutical applications. The molecular mechanisms underlying the intimate link between histone modifications, DNA methylation, gene silencing and human diseases are still poorly understood and deciphering these mechanisms represent one of the current major challenge in molecular biology. Overall, the goal of our work is to elucidate the molecular mechanisms by which the epigenetic machineries (associated with DNA methylation, histone methylation, deacetylation, ') functions and how there alterations can lead to human pathologies, such as cancer. Our study should factor significantly not only into understanding of gene expression but also into the abnormal processes which lead to oncogenesis.