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In vivo gene delivery in the basal ganglia.

Units : Laboratory of Experimental Neurosurgery | ULB257

Description :

In vivo gene delivery in the brain using adeno-associated virus-based (AAV) vectors. We have shown that AAV vectors can drive
stable gene expression (at least one year) in the brain with however a variable efficacy and durability. In the globus pallidus, gene
expression es early and efficient whereas in the striatum, a potential target for the treatment of Huntington and Parkinson's
diseases, it  is stable but not efficient. New vectors developed in another theme are currently evaluated.

List of persons in charge :

  • TENENBAUM Liliane

List of lessors :

  • F.R.S.-FNRS et Fonds associés (hors FRIA)

  • Fonds associés (toutes subventions, y compris la Loterie Nat.)

  • Autres fonds publics belges

  • Autres U.E.