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Ex vivo gene delivery to fetal nervous tissue used for cell replacement therapy by means of adeno-associated viruses (AAV)-based vectors. We have shown that AAV vectorsare particularly efficient to transfer genes in human embryonic mesencephalon. New constructs expressing protective factors will be developped to improve the survival of the transplanted cells. In collaboration with M. Peschanski (INSERM, Paris), AAV-mediated transfer of GDNF (glial cell line-derived neurotrophic factor) gene promoting dopaminergic neuron survival, into the embryonic mesencephalon prior to transplantation.
• F.R.S.-FNRS et Fonds associés (hors FRIA)
• Fonds associés (toutes subventions, y compris la Loterie Nat.)
• Autres fonds publics belges
• Autres U.E.