This research project is devoted to the analysis of the etiopathogeny of Alzheimer's disease, a frequent neurodegenerative disease
associated to brain aging. We study the cellular lesions of the disease in brain tissue of patients, and in cellular and
transgenic models reproducing these lesions. These experimental models are analyzed by histological and biochemical methods, with the aim
of investigating functional changes of keys-proteins (tau proteins, APP protein) involved in the development of the disease and
how these proteins interact to induce cellular lesions of Alzheimer's disease. These models are also used to test potential
therapeutic approachs interfering with the formation of the cellular lesions.